DeAngelo Williams, RB, Carolina Panthers
The major fantasy setback for Williams this year is that he has had to share carries with Cam Newton as well as two capable backups, Jonathan Stewart and Mike Tolbert. With Stewart injured and Tolbert acting more as a fullback now, evidenced by his one carry last week, Williams is set up to prosper. Additionally, it can't hurt that he gets to go up against the 26th ranked fantasy run defense of the Atlanta Falcons.
Cordarrelle Patterson, WR, Minnesota Vikings
Early in the season Patterson put his athleticism on display in the return game, but now the Vikings have started to allow him to show off his skills in their normal offense. He has more than ten fantasy points in each of the last three weeks, which is a product of the Vikings desire to get the ball in his hands in whatever way possible. In a meaningless game against the Lions on Sunday, the Vikings will likely put the ball in Patterson's hands often to see what they truly have in their first round pick.
Ben Roethlisberger, QB, Pittsburgh Steelers
Roethlisberger has had a sneakily good season, and going up against the 23rd ranked Browns fantasy defense, you would expect him to produce. Averaging over two touchdowns per game over the past eight weeks, Roethlisberger looks primed for another successful week.
Frank Gore, RB, San Francisco 49ers
Gore has had a good season, but he has been a bit inconsistent at times. My guess is that this week is not one of his better weeks, in a tough matchup against the Arizona Cardinals, who have allowed the fewest yards to opposing running backs. This defense has allowed just four touchdowns to running backs all year in addition to just two weeks of allowing over one hundred rushing yards... That's pretty good.
Harry Douglas, WR, Atlanta Falcons
It was nice while it lasted, but it seems as if Douglas' time in the spotlight is over, with Roddy White finally returning to his old form with a huge game against the 49ers last week. Even when White was not producing, Douglas' numbers were not entirely encouraging, as he has not scored more than seven fantasy points in the last five weeks. To make matters worse, he has to go up against a Panthers defense that is second in allowing fantasy points to opposing wide receivers.
Tom Brady, QB, New England Patriots
Tom Brady's number one target is a former quarterback at Kent State... That shouldn't be a recipe for success. However it was worked out well for the 11-4 Patriots who currently sit comfortably atop the AFC East. This week, though, the Patriots face up against the Bills, and I believe that the talented cornerback duo of Leodis McKelvin and Stephon Gilmore along with a talented front seven featuring Kiko Alonso, Marcel Dareus, Kyle Williams, and Mario Williams, will be able to expose the Patriots lack of receiving options, making for a difficult fantasy week for Tom Brady.