Colin Kaepernick, QB, San Francisco 49ers - In many 8 or 10 team leagues, Kaepernick will have ended up as a high-end backup. However, this week he shouldn't be sitting on your bench, regardless of what quarterback you need to bench to make way for him in the starting lineup. Kaepernick is going up against a Cowboys defense that was one of the worst pass defenses in the entire NFL last season and did very little to improve that over the offseason.
Mark Ingram, RB, New Orleans Saints - The Saints' running back situation has been somewhat of a carousel over the last few years, with no one back able to cement himself as a reliable player at the position. This preseason, though, Mark Ingram has been dominant, and the 2011 first round draft pick is finally looking like he is going to live up to his potential. What's remarkable about this situation is that, despite the lack of premier running backs in the NFL, Ingram hasn't even been picked up in 100 percent of leagues. If he's still a free agent in your league, you need to pick him up NOW, and maybe even consider him for your RB2 or flex spot as he has a fairly easy matchup against the Falcons.
Marquise Lee, WR, Jacksonville Jaguars - Now that Cecil Shorts has been labeled as "out" for the game against the Eagles and Ace Sanders has been suspended for the first four games, Lee is the only half-respectable fantasy target for the Jags, and he's currently available in most ESPN leagues. You would have to be fairly desperate for a flex spot to pull this move, but he is going up against one of the worst pass defenses in the NFL (that of the Philadelphia Eagles) and Chad Henne has to throw to someone, right? Right? RIGHT?
Joe Flacco, QB, Baltimore Ravens - My honest pick for a "sit 'em" quarterback this week would have been Aaron Rodgers, but considering he already played and sorely underperformed, that would really be cheating. So, here I'll tell you to sit Joe Flacco, but only if you have a fairly strong backup. Flacco doesn't have a great matchup against the Bengals, but I doubt that he'll absolutely implode. Thus, proceed with caution when sitting Flacco, but, in many situations it would probably be the right move.
DeAngelo Williams, RB, Carolina Panthers - Williams' yard totals should be decent enough this year, but with Jonathan Stewart, Mike Tolbert, and Cam Newton taking away from his red zone carries, he doesn't really hold much value unless one of the others gets injured or he has a great matchup. This week certainly isn't a good matchup, as Williams will go up against a Buccaneers' run defense that was one of the better run units in the entire league last year.
Golden Tate, WR, Detroit Lions - Tate was a legitimate WR2 last season, but that was in Seattle, where other wide receiver options were often scarce. In Detroit, other wide receiver options will be anything but scarce, as the best wide receiver in the NFL, Calvin Johnson, will demand most of the targets. In games against weak pass defenses Tate might be worth a look, but he goes up against the Giants this week, who were actually fairly impressive on pass defense last season. Tate may end up being a solid spot-start wide receiver, but this week is one of those weeks when you should keep him on your bench.